Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.64 |
| ▸ | PDE11A | Q9HCR9 | 12/20 | 0.64 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13920096 | 1.00 | PDE4B (0.64) | PDE4BPDE11APDE10A | |
| SCHEMBL13919976 | 1.00 | PDE4B (0.64) | PDE4BPDE11APDE10A | |
| SCHEMBL13919981 | 0.93 | PDE4B (0.62) | PDE4BPDE11APDE10A | |
| SCHEMBL13920055 | 0.92 | PDE4B (0.62) | PDE4BPDE11APDE10A | |
| SCHEMBL13920115 | 0.91 | PDE4B (0.63) | PDE4BPDE11APDE10A | |
| SCHEMBL12162855 | 0.90 | PDE4B (0.69) | PDE4BPDE11APDE10A | |
| SCHEMBL13920118 | 0.90 | PDE4B (0.62) | PDE4BPDE11APDE10A | |
| SCHEMBL13920114 | 0.90 | PDE4B (0.58) | PDE4BPDE11APDE10A | |
| SCHEMBL13920014 | 0.89 | PDE4B (0.63) | PDE4BPDE11APDE10A | |
| SCHEMBL13919982 | 0.89 | PDE4B (0.63) | PDE4BPDE11APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8802684-B2 | Adenine derivatives | GLAXOSMITHKLINE LLC (US) | 2014-08-12 | — | — | US | disclosed |
| US-7511062-B2 | Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors | SCHERING CORPORATION (US) | 2009-03-31 | — | — | US | disclosed |
| US-7511062-B2 | Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors | SCHERING CORPORATION (US) | 2009-03-31 | — | — | US | disclosed |