Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Leucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.55 |
| ▸ | SLC1A3 | P43003 | 4/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.39 |
| ▸ | DPP4 | P27487 | 3/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 2/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.35 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.35 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL27191662 | 1.00 | SLC7A5 (0.55) | SLC7A5SLC1A3SLC1A2SLC1A1DPP4 | |
| Leucine SCHEMBL17113855 | 1.00 | SLC7A5 (0.55) | SLC7A5SLC1A3SLC1A2SLC1A1DPP4 | |
| Leucine SCHEMBL756553 | 1.00 | SLC7A5 (0.55) | SLC7A5SLC1A3SLC1A2SLC1A1DPP4 | |
| Leucine SCHEMBL29092653 | 1.00 | SLC7A5 (0.55) | SLC7A5SLC1A3SLC1A2SLC1A1DPP4 | |
| Leucine SCHEMBL756554 | 1.00 | SLC7A5 (0.55) | SLC7A5SLC1A3SLC1A2SLC1A1DPP4 | |
| D-Leucine SCHEMBL1537225 | 1.00 | SLC7A5 (0.55) | SLC7A5SLC1A3SLC1A2SLC1A1DPP4 | |
| Leucine SCHEMBL139230 | 1.00 | SLC7A5 (0.55) | SLC7A5SLC1A3SLC1A2SLC1A1DPP4 | |
| Leucine SCHEMBL5060410 | 1.00 | SLC7A5 (0.55) | SLC7A5SLC1A3SLC1A2SLC1A1DPP4 | |
| Leucine SCHEMBL17113857 | 1.00 | SLC7A5 (0.55) | SLC7A5SLC1A3SLC1A2SLC1A1DPP4 | |
| Leucine SCHEMBL8817376 | 0.97 | SLC7A5 (0.51) | SLC7A5SLC1A3SLC1A2SLC1A1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3122902-A1 | METHOD OF PREDICTING THE TUMOR RESPONSE TO DNA METHYLATION INHIBITORS AND ALTERNATIVE THERAPEUTIC REGIMEN FOR OVERCOMING RESISTANCE | Palacký University In Olomouc (CZ) | 2017-02-01 | — | — | EP | claimed |
| WO-2015144102-A1 | METHOD OF PREDICTING THE TUMOR RESPONSE TO DNA METHYLATION INHIBITORS AND ALTERNATIVE THERAPEUTIC REGIMEN FOR OVERCOMING RESISTANCE | PALACKY UNIVERSITY, OLOMOUC (CZ) | 2015-10-01 | — | — | WO | claimed |
| EP-2900206-A2 | USE OF A COMBINATION OF AT LEAST ONE POLYUNSATURATED FATTY ACID AND AT LEAST ONE CAROTENOID, FOR IMPROVING THE QUALITY OF THE NAILS | Laboratoires Inneov (FR) | 2015-08-05 | — | — | EP | claimed |
| US-20150208683-A1 | EDIBLE WATER-IN-OIL EMULSION AND A PROCESS FOR PREPARING SUCH EMULSION | CONOPCO, INC., D/B/A UNILEVER (US) | 2015-07-30 | — | — | US | claimed |
| EP-2897464-A1 | EDIBLE WATER-IN-OIL EMULSION AND A PROCESS FOR PREPARING SUCH EMULSION | Unilever N.V. (NL) | 2015-07-29 | — | — | EP | claimed |
| WO-2014044582-A1 | EDIBLE WATER-IN-OIL EMULSION AND A PROCESS FOR PREPARING SUCH EMULSION | UNILEVER N.V. (NL) | 2014-03-27 | — | — | WO | claimed |
| EP-2482678-B1 | CHEESE AND METHOD FOR ITS MANUFACTURING | VALIO LTD (FI) | 2013-07-10 | — | — | EP | claimed |
| EP-2482678-A1 | CHEESE AND METHOD FOR ITS MANUFACTURING | Valio Ltd. (FI) | 2012-08-08 | — | — | EP | claimed |
| US-20120183644-A1 | CHEESE AND METHOD FOR ITS MANUFACTURING | VALIO LTD. (FI) | 2012-07-19 | — | — | US | claimed |
| WO-2011039414-A1 | CHEESE AND METHOD FOR ITS MANUFACTURING | VALIO LTD (FI) | 2011-04-07 | — | — | WO | claimed |
| EP-3122902-A1 | METHOD OF PREDICTING THE TUMOR RESPONSE TO DNA METHYLATION INHIBITORS AND ALTERNATIVE THERAPEUTIC REGIMEN FOR OVERCOMING RESISTANCE | Palacký University In Olomouc (CZ) | 2017-02-01 | — | — | EP | disclosed |
| EP-2897464-B1 | EDIBLE WATER-IN-OIL EMULSION AND A PROCESS FOR PREPARING SUCH EMULSION | UNILEVER NV (NL) | 2015-12-09 | — | — | EP | disclosed |
| WO-2015144102-A1 | METHOD OF PREDICTING THE TUMOR RESPONSE TO DNA METHYLATION INHIBITORS AND ALTERNATIVE THERAPEUTIC REGIMEN FOR OVERCOMING RESISTANCE | PALACKY UNIVERSITY, OLOMOUC (CZ) | 2015-10-01 | — | — | WO | disclosed |
| EP-2900205-A2 | USE OF A COMBINATION OF TAURINE OR A DERIVATE THEREOF AND A GRAPE EXTRACT FOR IMPROVING THE QUALITY OF THE NAILS | Laboratoires Inneov (FR) | 2015-08-05 | — | — | EP | disclosed |
| US-20150208683-A1 | EDIBLE WATER-IN-OIL EMULSION AND A PROCESS FOR PREPARING SUCH EMULSION | CONOPCO, INC., D/B/A UNILEVER (US) | 2015-07-30 | — | — | US | disclosed |
| US-20100022747-A1 | PROPHYLACTIC AGENT FOR HEART FAILURE | CALPIS CO., LTD. (JP) | 2010-01-28 | — | — | US | disclosed |
| US-20100022748-A1 | PROPHYLACTIC AGENT FOR RENAL FAILURE | CALPIS CO., LTD. (JP) | 2010-01-28 | — | — | US | disclosed |
| EP-2138184-A1 | PROPHYLACTIC AGENT FOR RENAL FAILURE | Calpis Co., Ltd. (JP) | 2009-12-30 | — | — | EP | disclosed |
| EP-2130546-A1 | PROPHYLACTIC AGENT FOR HEART FAILURE | Calpis Co., Ltd. (JP) | 2009-12-09 | — | — | EP | disclosed |
| US-20090298773-A1 | METHODS OF PRODUCING FUNCTIONAL MISO | MARUKOME CO., LTD. (JP) | 2009-12-03 | — | — | US | disclosed |