Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 12/20 | 0.41 |
| ▸ | WNT1 | P04628 | 7/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 8/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13923945 | 1.00 | CHRNA7 (0.41) | CHRNA7HTR3ADYRK1AWNT1CLK2 | |
| SCHEMBL13923944 | 1.00 | CHRNA7 (0.41) | CHRNA7HTR3ADYRK1AWNT1CLK2 | |
| SCHEMBL2087360 | 0.81 | GSK3B (0.45) | CHRNA7HTR3ADYRK1AWNT1GSK3B | |
| SCHEMBL2087347 | 0.81 | GSK3B (0.45) | CHRNA7HTR3ADYRK1AWNT1GSK3B | |
| SCHEMBL2088971 | 0.81 | GSK3B (0.45) | CHRNA7HTR3ADYRK1AWNT1GSK3B | |
| SCHEMBL2086463 | 0.80 | CHRNA7 (0.61) | CHRNA7HTR3AKDM4EGAAKMT2A | |
| Hydrochloric Acid SCHEMBL2085876 | 0.79 | CHRNA7 (0.60) | CHRNA7HTR3AKDM4EGAAKMT2A | |
| SCHEMBL1458602 | 0.79 | CHRNA7 (0.66) | CHRNA7HTR3ADYRK1AWNT1GSK3B | |
| SCHEMBL29749352 | 0.79 | CHRNA7 (0.66) | CHRNA7HTR3ADYRK1AWNT1GSK3B | |
| SCHEMBL1459315 | 0.79 | CHRNA7 (0.66) | CHRNA7HTR3ADYRK1AWNT1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7488737-B2 | Indoles, 1H-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof | MEMORY PHARMACEUTICAL CORPORATION (US) | 2009-02-10 | — | — | US | disclosed |
| US-7488737-B2 | Indoles, 1H-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof | MEMORY PHARMACEUTICAL CORPORATION (US) | 2009-02-10 | — | — | US | disclosed |