Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | BCL2 | P10415 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.30 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.30 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL330152 | 0.91 | ADRB3 (0.36) | ADRB3ADRA2BADRA2CALDH1A1KDM4E | |
| SCHEMBL3968261 | 0.91 | ADRB3 (0.36) | ADRB3ADRA2BADRA2CALDH1A1KDM4E | |
| SCHEMBL3971549 | 0.91 | ADRB3 (0.36) | ADRB3ADRA2BADRA2CALDH1A1KDM4E | |
| SCHEMBL3968264 | 0.91 | ADRB3 (0.36) | ADRB3ADRA2BADRA2CALDH1A1KDM4E | |
| SCHEMBL3968258 | 0.91 | ADRB3 (0.36) | ADRB3ADRA2BADRA2CALDH1A1KDM4E | |
| SCHEMBL3971556 | 0.91 | ADRB3 (0.36) | ADRB3ADRA2BADRA2CALDH1A1KDM4E | |
| SCHEMBL330154 | 0.91 | ADRB3 (0.36) | ADRB3ADRA2BADRA2CALDH1A1KDM4E | |
| SCHEMBL3965120 | 0.90 | ADRB3 (0.45) | ADRB3ADRA2BADRA2CALDH1A1KDM4E | |
| SCHEMBL3965128 | 0.90 | ADRB3 (0.45) | ADRB3ADRA2BADRA2CALDH1A1KDM4E | |
| SCHEMBL3965124 | 0.90 | ADRB3 (0.45) | ADRB3ADRA2BADRA2CALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7491794-B2 | Macrocyclic compounds as inhibitors of viral replication | INTERMUNE, INC. (US) | 2009-02-17 | — | — | US | disclosed |
| US-7491794-B2 | Macrocyclic compounds as inhibitors of viral replication | INTERMUNE, INC. (US) | 2009-02-17 | — | — | US | disclosed |