Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | BCL2 | P10415 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3968301 | 0.94 | ADRB3 (0.48) | ADRB3ADRA2BADRA2CPOLBALDH1A1 | |
| SCHEMBL3968316 | 0.94 | ADRB3 (0.48) | ADRB3ADRA2BADRA2CPOLBALDH1A1 | |
| SCHEMBL3968307 | 0.94 | ADRB3 (0.48) | ADRB3ADRA2BADRA2CPOLBALDH1A1 | |
| SCHEMBL3970706 | 0.93 | ADRB3 (0.50) | ADRB3ADRA2BADRA2CPOLBALDH1A1 | |
| SCHEMBL3974766 | 0.93 | ADRB3 (0.50) | ADRB3ADRA2BADRA2CPOLBALDH1A1 | |
| SCHEMBL3974770 | 0.93 | ADRB3 (0.50) | ADRB3ADRA2BADRA2CPOLBALDH1A1 | |
| SCHEMBL3973321 | 0.93 | ADRB3 (0.50) | ADRB3ADRA2BADRA2CPOLBDPP8 | |
| SCHEMBL3973322 | 0.93 | ADRB3 (0.50) | ADRB3ADRA2BADRA2CPOLBDPP8 | |
| SCHEMBL3973320 | 0.93 | ADRB3 (0.50) | ADRB3ADRA2BADRA2CPOLBDPP8 | |
| SCHEMBL3965585 | 0.91 | ADRB3 (0.46) | ADRB3ADRA2BADRA2CDRD2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7491794-B2 | Macrocyclic compounds as inhibitors of viral replication | INTERMUNE, INC. (US) | 2009-02-17 | — | — | US | disclosed |