Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 5/20 | 0.39 |
| ▸ | SORD | Q00796 | 3/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8987971 | 0.90 | EIF2AK4 (0.40) | EIF2AK4SORDHSD11B1WNT3APIK3CD | |
| SCHEMBL8985979 | 0.89 | EIF2AK4 (0.38) | EIF2AK4SORDHSD11B1PIK3CD | |
| SCHEMBL8987864 | 0.87 | EIF2AK4 (0.38) | EIF2AK4SORDHSD11B1SLC6A7 | |
| SCHEMBL12341821 | 0.87 | EIF2AK4 (0.37) | EIF2AK4SORDHSD11B1 | |
| SCHEMBL8990365 | 0.85 | EIF2AK4 (0.36) | EIF2AK4SORDHSD11B1WNT3AHCAR2 | |
| SCHEMBL8988012 | 0.84 | JAK3 (0.38) | EIF2AK4WNT3A | |
| SCHEMBL12341823 | 0.83 | EIF2AK4 (0.34) | EIF2AK4SORDHSD11B1 | |
| SCHEMBL8988167 | 0.81 | EIF2AK4 (0.34) | EIF2AK4SORDWNT3A | |
| SCHEMBL8990162 | 0.81 | TSHR (0.38) | EIF2AK4WNT3A | |
| SCHEMBL8987784 | 0.75 | EIF2AK4 (0.38) | EIF2AK4SORDHSD11B1HCAR2SLC6A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7507826-B2 | Such as 3-(2-Methanesulfonyl-pyrimidin-4-yl)-5-pyridin-3-yl-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine; heart disease, diabetes, Alzheimer's disease, immunodeficiency disorders, inflammatory diseases, hypertension, allergic diseases, autoimmune diseases, destructive bone disorders | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-03-24 | — | — | US | disclosed |