Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 15/20 | 0.84 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.76 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.76 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.76 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.76 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.76 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.76 |
| ▸ | MMP1 | P03956 | 4/20 | 0.68 |
| ▸ | MMP2 | P08253 | 1/20 | 0.68 |
| ▸ | MMP7 | P09237 | 1/20 | 0.68 |
| ▸ | MMP10 | P09238 | 1/20 | 0.68 |
| ▸ | MMP9 | P14780 | 1/20 | 0.68 |
| ▸ | MMP13 | P45452 | 1/20 | 0.68 |
| ▸ | MMP14 | P50281 | 1/20 | 0.68 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.68 |
| ▸ | MMP3 | P08254 | 3/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4497047 | 1.00 | APP (0.84) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL13934741 | 0.95 | APP (0.82) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4479419 | 0.95 | APP (0.82) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL13934574 | 0.95 | APP (0.82) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL13934640 | 0.93 | APP (0.79) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4483193 | 0.93 | APP (0.79) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4488173 | 0.91 | APP (0.75) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4478859 | 0.90 | APP (0.75) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL13934746 | 0.90 | APP (0.75) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4488557 | 0.90 | PSEN1 (0.78) | APPPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7507815-B2 | Succinoylamino lactams as inhibitors of a-β protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2009-03-24 | — | — | US | disclosed |
| US-20080293692-A1 | SUCCINOYLAMINO LACTAMS AS INHIBITORS OF A-BETA PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293692-A1 | SUCCINOYLAMINO LACTAMS AS INHIBITORS OF A-BETA PROTEIN PRODUCTION | BACE1, APH1A, APP | APP 3/4885PSEN1 7/4885PSEN2 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.