Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK3 | O43781 | 5/20 | 0.67 |
| ▸ | CDK1 | P06493 | 4/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.52 |
| ▸ | GSK3B | P49841 | 3/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | GSK3A | P49840 | 1/20 | 0.52 |
| ▸ | CDK7 | P50613 | 1/20 | 0.52 |
| ▸ | CDK9 | P50750 | 1/20 | 0.52 |
| ▸ | CCNH | P51946 | 1/20 | 0.52 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.52 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | CLK1 | P49759 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2789892 | 1.00 | DYRK3 (0.67) | DYRK3CDK1PRKCDGSK3BCCNB1 | |
| SCHEMBL2789895 | 1.00 | DYRK3 (0.67) | DYRK3CDK1PRKCDGSK3BCCNB1 | |
| SCHEMBL2788194 | 0.87 | DYRK3 (0.67) | DYRK3CDK1PRKCDGSK3BCCNB1 | |
| SCHEMBL13197020 | 0.87 | DYRK3 (0.67) | DYRK3CDK1PRKCDGSK3BCCNB1 | |
| SCHEMBL2788188 | 0.87 | DYRK3 (0.67) | DYRK3CDK1PRKCDGSK3BCCNB1 | |
| SCHEMBL4770650 | 0.86 | DYRK3 (0.48) | DYRK3GSK3BCLK1CLK3DYRK1A | |
| SCHEMBL13196821 | 0.81 | DYRK3 (1.00) | DYRK3CDK1PRKCDGSK3BCCNB1 | |
| SCHEMBL2786117 | 0.81 | DYRK3 (1.00) | DYRK3CDK1PRKCDGSK3BCCNB1 | |
| SCHEMBL2786118 | 0.81 | DYRK3 (1.00) | DYRK3CDK1PRKCDGSK3BCCNB1 | |
| SCHEMBL2786592 | 0.81 | DYRK3 (0.73) | DYRK3CDK1PRKCDGSK3BCCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023742-A1 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION | 2009-01-22 | — | — | US | disclosed |
| US-20090023742-A1 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023742-A1 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | PIK3CA, BTK, PI4KA | DYRK3 1357/4885CDK1 723/4885PRKCD 886/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.