Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.34 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.34 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.34 |
| ▸ | PRKCG | P05129 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.34 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.34 |
| ▸ | CSNK1G3 | Q9Y6M4 | 2/20 | 0.34 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2639974 | 0.89 | BRAF (0.40) | ACVR1BRAFMAPK8MAPK9PRKD3 | |
| SCHEMBL13941231 | 0.83 | ACVR1 (0.42) | ACVR1BRAFPRKD3PRKCGPIM1 | |
| SCHEMBL2957753 | 0.82 | BRAF (0.38) | ACVR1BRAFMAPK8MAPK9PRKD3 | |
| SCHEMBL13941220 | 0.80 | ACVR1 (0.44) | ACVR1BRAFPRKD3PRKCGEGFR | |
| SCHEMBL13940233 | 0.79 | BRAF (0.38) | ACVR1BRAFMAPK8MAPK9PRKD3 | |
| SCHEMBL13940914 | 0.77 | BRAF (0.38) | ACVR1BRAFMAPK8MAPK9PRKD3 | |
| SCHEMBL2639985 | 0.77 | BRAF (0.52) | BRAFMAPK8MAPK9CSNK1A1GSK3B | |
| SCHEMBL13939892 | 0.77 | BRAF (0.38) | ACVR1BRAFPRKD3MAP4K4CSNK1A1 | |
| SCHEMBL2639759 | 0.75 | BRAF (0.64) | BRAFMAPK8MAPK9CSNK1A1GSK3B | |
| SCHEMBL2639623 | 0.75 | ACVR1 (0.44) | ACVR1BRAFDYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009016460-A2 | PYRAZOLE COMPOUNDS AND THEIR USE AS RAF INHIBITORS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |