Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 6/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14431119 | 0.95 | PTGER4 (0.49) | PTGER4CYP1A2CYP2D6SMN1; SMN2RECQL | |
| SCHEMBL13941753 | 0.93 | PTGER4 (0.67) | PTGER4CYP1A2CYP2D6SMN1; SMN2RECQL | |
| SCHEMBL14431118 | 0.89 | PTGER4 (0.59) | PTGER4CYP1A2CYP2D6SMN1; SMN2ALDH1A1 | |
| SCHEMBL4031837 | 0.85 | PTGER4 (0.65) | PTGER4CYP1A2CYP2D6ALDH1A1HPGD | |
| SCHEMBL14431121 | 0.85 | PTGER4 (0.51) | PTGER4CYP1A2CYP2D6SMN1; SMN2RECQL | |
| SCHEMBL10058499 | 0.84 | PTGER4 (0.57) | PTGER4CYP1A2CYP2D6SMN1; SMN2RECQL | |
| SCHEMBL13942024 | 0.84 | PTGER4 (0.69) | PTGER4CYP1A2CYP2D6ALDH1A1HPGD | |
| SCHEMBL13942570 | 0.83 | PTGER4 (0.59) | PTGER4CYP1A2CYP2D6ALDH1A1POLB | |
| SCHEMBL13942321 | 0.83 | PTGER4 (0.53) | PTGER4CYP1A2CYP2D6SMN1; SMN2RECQL | |
| SCHEMBL12002092 | 0.82 | PTGER4 (0.47) | PTGER4CYP1A2CYP2D6SMN1; SMN2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009019281-A1 | BENZOISOINDOLE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR AGONISTS FOR THE TREATMENT OF PAIN | GLAXO GROUP LIMITED (GB) | 2009-02-12 | — | — | WO | disclosed |