Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 3/20 | 0.76 |
| ▸ | GRM2 | Q14416 | 10/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | STK3 | Q13188 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.42 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12743472 | 0.86 | GRK2 (0.78) | GRK2GRM2AURKAROCK2CSF1R | |
| SCHEMBL12743418 | 0.86 | GRK2 (1.00) | GRK2GRM2AURKACSF1RKDR | |
| SCHEMBL8255264 | 0.86 | GRK2 (0.77) | GRK2GRM2 | |
| SCHEMBL8251793 | 0.85 | GRK2 (0.71) | GRK2GRM2ROCK2FLT3ROCK1 | |
| SCHEMBL12743414 | 0.81 | GRK2 (0.70) | GRK2GRM2ROCK2ROCK1ALDH1A1 | |
| SCHEMBL8250104 | 0.80 | GRK2 (0.67) | GRK2GRM2BTKLCK | |
| SCHEMBL8254623 | 0.79 | GRK2 (0.60) | GRK2GRM2 | |
| SCHEMBL8253701 | 0.77 | GRK2 (0.67) | GRK2ROCK2ROCK1 | |
| SCHEMBL8255399 | 0.77 | GRK2 (0.67) | GRK2GRM2TYK2 | |
| SCHEMBL8253714 | 0.77 | GRK2 (0.61) | GRK2GRM2AURKAROCK2ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899333-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS INHIBITORS OF BETA-ADRENERGIC RECEPTOR KINASE 1 | SANOFI AVENTIS (FR) | 2009-02-18 | — | — | EP | disclosed |