Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 17/20 | 0.55 |
| ▸ | CXCR1 | P25024 | 14/20 | 0.55 |
| ▸ | CCR7 | P32248 | 1/20 | 0.35 |
| ▸ | PDE8B | O95263 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13947617 | 0.89 | CXCR2 (0.42) | CXCR2CXCR1CCR7CLK1CLK2 | |
| SCHEMBL13947940 | 0.87 | CXCR2 (0.41) | CXCR2CXCR1CCR7CLK1CLK2 | |
| SCHEMBL13947991 | 0.87 | CXCR2 (0.41) | CXCR2CXCR1CCR7CLK1CLK2 | |
| SCHEMBL13948381 | 0.85 | CXCR2 (0.40) | CXCR2CXCR1PDE8B | |
| SCHEMBL13948304 | 0.84 | CXCR1 (0.42) | CXCR2CXCR1PDE8BNPC1CLK1 | |
| SCHEMBL13948002 | 0.83 | CXCR2 (0.44) | CXCR2CXCR1 | |
| SCHEMBL13207009 | 0.82 | CXCR2 (0.79) | CXCR2CXCR1CCR7 | |
| SCHEMBL13207196 | 0.81 | CXCR2 (0.78) | CXCR2CXCR1CCR7 | |
| SCHEMBL14100259 | 0.80 | CXCR1 (0.40) | CXCR2CXCR1 | |
| SCHEMBL13947999 | 0.79 | CXCR2 (0.46) | CXCR2CXCR1CCR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551818-B1 | THIADIAZOLEDIOXIDES AND THIADIAZOLEOXIDES AS CXC- AND CC-CHEMOKINE RECEPTOR LIGANDS | SCHERING CORP (US) | 2009-02-04 | — | — | EP | disclosed |
| EP-1694659-B1 | THIADIAZOLES AS CXC- AND CC- CHEMOKINE RECEPTOR LIGANDS | SCHERING CORP (US) | 2008-08-27 | — | — | EP | disclosed |