Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 14/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 5/20 | 0.40 |
| ▸ | ASPH | Q12797 | 1/20 | 0.39 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TACR3 | P29371 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13406919 | 1.00 | KDM4E (0.43) | KDM4EALDH1A1LMNAHPGDTSHR | |
| SCHEMBL13406925 | 0.87 | KCNA5 (0.38) | KDM4EALDH1A1LMNAHPGDTSHR | |
| SCHEMBL13947954 | 0.86 | CXCR2 (0.41) | KDM4EALDH1A1LMNAHPGDTSHR | |
| SCHEMBL13406921 | 0.86 | CXCR2 (0.41) | KDM4EALDH1A1LMNAHPGDTSHR | |
| SCHEMBL13440222 | 0.84 | CXCR2 (0.43) | KDM4EALDH1A1LMNAHPGDTSHR | |
| SCHEMBL13406917 | 0.84 | KDM4E (0.34) | KDM4EALDH1A1LMNAHPGDTSHR | |
| SCHEMBL13406918 | 0.83 | CXCR2 (0.44) | KDM4EALDH1A1LMNAHPGDCXCR2 | |
| SCHEMBL13439920 | 0.82 | CXCR2 (0.42) | CXCR2CXCR1 | |
| SCHEMBL13406928 | 0.82 | CXCR2 (0.65) | KDM4EALDH1A1LMNAHPGDTSHR | |
| SCHEMBL13406923 | 0.82 | CXCR2 (0.42) | CXCR2CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551818-B1 | THIADIAZOLEDIOXIDES AND THIADIAZOLEOXIDES AS CXC- AND CC-CHEMOKINE RECEPTOR LIGANDS | SCHERING CORP (US) | 2009-02-04 | — | — | EP | disclosed |