Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 13/20 | 0.48 |
| ▸ | CXCR1 | P25024 | 9/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | CCR7 | P32248 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13407385 | 0.89 | CXCR2 (0.61) | CXCR2CXCR1CCR6CCR7 | |
| SCHEMBL13406984 | 0.84 | CXCR2 (0.67) | CXCR2CXCR1CCR6CCR7 | |
| SCHEMBL13947585 | 0.72 | CXCR2 (0.35) | CXCR2CXCR1JAK1TYK2 | |
| SCHEMBL13406880 | 0.71 | CXCR2 (0.64) | CXCR2CXCR1CCR6 | |
| SCHEMBL13406876 | 0.71 | CXCR2 (0.66) | CXCR2CXCR1CCR6 | |
| SCHEMBL13407010 | 0.71 | CXCR2 (0.53) | CXCR2CXCR1CCR7 | |
| SCHEMBL13948030 | 0.71 | CXCR2 (0.54) | CXCR2CXCR1JAK1TYK2 | |
| SCHEMBL13407334 | 0.71 | CXCR2 (0.58) | CXCR2CXCR1CCR7 | |
| SCHEMBL13405726 | 0.71 | CXCR1 (0.69) | CXCR2CXCR1CCR6CCR7 | |
| SCHEMBL13407000 | 0.71 | CXCR2 (0.51) | CXCR2CXCR1CCR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551818-B1 | THIADIAZOLEDIOXIDES AND THIADIAZOLEOXIDES AS CXC- AND CC-CHEMOKINE RECEPTOR LIGANDS | SCHERING CORP (US) | 2009-02-04 | — | — | EP | disclosed |