Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 12/20 | 1.00 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 1.00 |
| ▸ | HDAC3 | O15379 | 9/20 | 1.00 |
| ▸ | HDAC2 | Q92769 | 9/20 | 1.00 |
| ▸ | HDAC4 | P56524 | 8/20 | 1.00 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 1.00 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 1.00 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 1.00 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 1.00 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 1.00 |
| ▸ | NAMPT | P43490 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13949772 | 0.88 | HDAC3 (0.78) | HDAC1HDAC8HDAC3HDAC2HDAC4 | |
| SCHEMBL8242058 | 0.84 | HDAC1 (0.72) | HDAC1HDAC8HDAC3HDAC2HDAC4 | |
| SCHEMBL4932223 | 0.81 | HDAC1 (0.67) | HDAC1HDAC8HDAC3HDAC2HDAC4 | |
| SCHEMBL4932231 | 0.81 | HDAC1 (0.67) | HDAC1HDAC8HDAC3HDAC2HDAC4 | |
| SCHEMBL4921853 | 0.80 | HDAC1 (0.67) | HDAC1HDAC8HDAC3HDAC2HDAC4 | |
| SCHEMBL4921863 | 0.80 | HDAC1 (0.67) | HDAC1HDAC8HDAC3HDAC2HDAC4 | |
| SCHEMBL13949775 | 0.79 | HDAC3 (0.65) | HDAC1HDAC8HDAC3HDAC2HDAC4 | |
| SCHEMBL14394210 | 0.79 | HDAC1 (0.73) | HDAC1HDAC8HDAC3HDAC2HDAC4 | |
| SCHEMBL4930692 | 0.76 | HDAC1 (0.61) | HDAC1HDAC8HDAC3HDAC2HDAC4 | |
| SCHEMBL4930691 | 0.76 | HDAC1 (0.61) | HDAC1HDAC8HDAC3HDAC2HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090012066-A1 | Method of Use of Deacetylase Inhibitors | NOVARTIS AG | 2009-01-08 | — | — | US | disclosed |
| US-20090012066-A1 | Method of Use of Deacetylase Inhibitors | NOVARTIS AG | 2009-01-08 | — | — | US | disclosed |
| US-20080176849-A1 | DEACETYLASE INHIBITORS | SECURA BIO, INC. | 2008-07-24 | — | — | US | disclosed |
| US-20080176849-A1 | DEACETYLASE INHIBITORS | SECURA BIO, INC. | 2008-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176849-A1 | DEACETYLASE INHIBITORS | HDAC1, HDAC3, HDAC6 | HDAC1 1/4885HDAC8 10/4885HDAC3 2/4885 |
| US-20090012066-A1 | Method of Use of Deacetylase Inhibitors | HDAC3, HDAC5, HDAC1 | HDAC1 3/4885HDAC8 8/4885HDAC3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.