Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 11/20 | 0.65 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | AKT1 | P31749 | 1/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.51 |
| ▸ | NEK2 | P51955 | 1/20 | 0.51 |
| ▸ | STK3 | Q13188 | 1/20 | 0.51 |
| ▸ | CAMK4 | Q16566 | 1/20 | 0.51 |
| ▸ | TSSK2 | Q96PF2 | 1/20 | 0.51 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 6/20 | 0.44 |
| ▸ | GPR6 | P46095 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13156340 | 0.92 | CHEK1 (0.78) | CHEK1JAK2ROCK2IGF1RMAPK1 | |
| SCHEMBL13323359 | 0.89 | CHEK1 (0.74) | CHEK1JAK2ROCK2IGF1RMAPK1 | |
| SCHEMBL13322864 | 0.80 | CHEK1 (0.78) | CHEK1JAK2ROCK2IGF1RMAPK1 | |
| SCHEMBL13156293 | 0.80 | BACE1 (0.58) | CHEK1IRAK4BACE1GPR6MAPT | |
| SCHEMBL13156316 | 0.79 | BACE1 (0.48) | CHEK1IRAK4BACE1GPR6 | |
| SCHEMBL13156341 | 0.79 | CHEK1 (1.00) | CHEK1JAK2ROCK2IGF1RMAPK1 | |
| SCHEMBL14038926 | 0.78 | CHEK1 (0.81) | CHEK1JAK2ROCK2IGF1RMAPK1 | |
| SCHEMBL13156307 | 0.78 | CHEK1 (0.74) | CHEK1JAK2ROCK2IGF1RMAPK1 | |
| SCHEMBL13156342 | 0.78 | CHEK1 (0.62) | CHEK1JAK2ROCK2IGF1RMAPK1 | |
| SCHEMBL13156308 | 0.77 | BACE1 (0.49) | CHEK1BACE1GPR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017701-A2 | ANTI-MITOTIC AGENT AND AURORA KINASE INHIBITOR COMBINATION AS ANTI-CANCER TREATMENT | SCHERING CORPORATION (US) | 2009-02-05 | — | — | WO | disclosed |