Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 16/20 | 0.72 |
| ▸ | AURKA | O14965 | 13/20 | 0.72 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.41 |
| ▸ | LCK | P06239 | 3/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8241728 | 0.84 | AURKB (1.00) | AURKBAURKACHEK1LCKIRAK4 | |
| SCHEMBL8241252 | 0.79 | AURKA (1.00) | AURKBAURKACHEK1LCKIRAK4 | |
| SCHEMBL12404520 | 0.79 | AURKB (0.76) | AURKBAURKACHEK1 | |
| SCHEMBL13955030 | 0.78 | AURKB (0.57) | AURKBAURKACHEK1LCKIRAK4 | |
| SCHEMBL8240362 | 0.77 | AURKB (0.88) | AURKBAURKACHEK1LCK | |
| SCHEMBL12404519 | 0.77 | AURKB (0.76) | AURKBAURKACHEK1LCKIRAK4 | |
| SCHEMBL12404516 | 0.75 | AURKB (0.74) | AURKBAURKACHEK1LCKRPS6KA3 | |
| SCHEMBL8240371 | 0.75 | AURKA (0.70) | AURKBAURKACHEK1FLT3 | |
| SCHEMBL15146142 | 0.73 | AURKB (0.71) | AURKBAURKACHEK1LCKFLT3 | |
| SCHEMBL12404507 | 0.73 | AURKA (0.81) | AURKBAURKACHEK1LCKIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017701-A2 | ANTI-MITOTIC AGENT AND AURORA KINASE INHIBITOR COMBINATION AS ANTI-CANCER TREATMENT | SCHERING CORPORATION (US) | 2009-02-05 | — | — | WO | disclosed |