Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.78 |
| ▸ | LCK | P06239 | 3/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 15/20 | 0.67 |
| ▸ | AURKA | O14965 | 13/20 | 0.67 |
| ▸ | KDR | P35968 | 2/20 | 0.64 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.64 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.64 |
| ▸ | CDK2 | P24941 | 1/20 | 0.64 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.64 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.64 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13955026 | 0.90 | CHEK1 (0.63) | CHEK1LCKAURKBAURKAKDR | |
| SCHEMBL8241428 | 0.88 | CHEK1 (1.00) | CHEK1LCKAURKBAURKAKDR | |
| SCHEMBL14536996 | 0.85 | CHEK1 (0.75) | CHEK1LCKAURKBAURKAKDR | |
| SCHEMBL14538388 | 0.83 | CHEK1 (0.56) | CHEK1LCKAURKBAURKAKDR | |
| SCHEMBL12471648 | 0.83 | CHEK1 (0.72) | CHEK1LCKAURKBAURKAKDR | |
| SCHEMBL13955027 | 0.82 | CHEK1 (0.54) | CHEK1LCKAURKBAURKAKDR | |
| SCHEMBL12473151 | 0.82 | LCK (1.00) | CHEK1LCKAURKBAURKAKDR | |
| SCHEMBL14536743 | 0.82 | CHEK1 (0.54) | CHEK1LCKAURKBAURKAKDR | |
| SCHEMBL14537069 | 0.82 | PTK6 (0.57) | CHEK1LCKAURKBAURKAPTK6 | |
| SCHEMBL14538382 | 0.81 | CHEK1 (0.53) | CHEK1LCKAURKBAURKAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017701-A2 | ANTI-MITOTIC AGENT AND AURORA KINASE INHIBITOR COMBINATION AS ANTI-CANCER TREATMENT | SCHERING CORPORATION (US) | 2009-02-05 | — | — | WO | disclosed |