Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 3/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.53 |
| ▸ | BRAF | P15056 | 6/20 | 0.53 |
| ▸ | KDR | P35968 | 4/20 | 0.53 |
| ▸ | TNNI3K | Q59H18 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | STAT1 | P42224 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 4/20 | 0.48 |
| ▸ | CDK7 | P50613 | 1/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1846790 | 0.81 | RAF1 (0.72) | RAF1MAPK14KDRNPC1RAB9A | |
| SCHEMBL1846138 | 0.81 | MAPK14 (0.49) | RAF1MAPK14BRAFMAPK13 | |
| SCHEMBL1846785 | 0.80 | RAF1 (0.64) | RAF1MAPK14CDK8MAPK13 | |
| SCHEMBL938903 | 0.78 | RAF1 (1.00) | RAF1MAPK14BRAFKDRTNNI3K | |
| SCHEMBL1506321 | 0.78 | RAF1 (0.74) | RAF1MAPK14BRAFKDRTNNI3K | |
| SCHEMBL1506293 | 0.78 | RAF1 (0.67) | RAF1MAPK14BRAFKDRTNNI3K | |
| SCHEMBL1396018 | 0.76 | RAF1 (0.63) | RAF1MAPK14BRAFKDRTNNI3K | |
| SCHEMBL7558282 | 0.75 | FFAR1 (0.55) | MAPK14HTTFAAH | |
| SCHEMBL12993349 | 0.74 | CYP1A2 (0.55) | LMNAMAPTMAPK1CA2 | |
| SCHEMBL32675964 | 0.74 | RAF1 (0.65) | RAF1MAPK14BRAFKDRTNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324825-A1 | Aryl ureas with angiogenesis inhibiting activity | Bayer Healthcare LLC (US) | 2011-05-25 | — | — | EP | claimed |
| EP-1478358-B1 | Sorafenib tosylate for the treatment of diseases characterized by abnormal angiogenesis | BAYER HEALTHCARE LLC (US) | 2013-07-03 | — | — | EP | disclosed |
| EP-2324825-A1 | Aryl ureas with angiogenesis inhibiting activity | Bayer Healthcare LLC (US) | 2011-05-25 | — | — | EP | disclosed |
| EP-2289515-A2 | Combinations comprising a diaryl urea and an interferon | Bayer HealthCare LLC (US) | 2011-03-02 | — | — | EP | disclosed |