Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 6/20 | 0.42 |
| ▸ | GSK3A | P49840 | 3/20 | 0.42 |
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | PIM1 | P11309 | 6/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 6/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.39 |
| ▸ | ATR | Q13535 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13961711 | 0.90 | CHEK1 (0.47) | CHEK1GSK3AGSK3BPIM1PIM3 | |
| SCHEMBL13028325 | 0.86 | GSK3B (0.44) | CHEK1GSK3AGSK3BPIM1PIM3 | |
| SCHEMBL13027875 | 0.86 | CHEK1 (0.55) | CHEK1GSK3AGSK3BPIM1PIM3 | |
| SCHEMBL13067931 | 0.86 | BACE1 (0.43) | CHEK1GSK3AGSK3BPIM1PIM3 | |
| SCHEMBL13961449 | 0.85 | GSK3B (0.42) | CHEK1GSK3AGSK3BPIM1PIM3 | |
| SCHEMBL13961491 | 0.84 | GSK3A (0.45) | CHEK1GSK3AGSK3BPIM1PIM3 | |
| SCHEMBL13961490 | 0.84 | CHEK1 (0.58) | CHEK1GSK3AGSK3BPIM1PIM3 | |
| SCHEMBL13961609 | 0.83 | GSK3B (0.46) | CHEK1GSK3AGSK3BPIM1PIM3 | |
| SCHEMBL13961454 | 0.81 | CHEK1 (0.56) | CHEK1GSK3AGSK3BPIM1PIM3 | |
| SCHEMBL13961452 | 0.81 | CHEK1 (0.45) | CHEK1GSK3AGSK3BPIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009014637-A2 | HETEROCYCLIC AMIDE COMPOUNDS AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2009-01-29 | — | — | WO | disclosed |