Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.70 |
| ▸ | JAK3 | P52333 | 14/20 | 0.64 |
| ▸ | JAK1 | P23458 | 8/20 | 0.63 |
| ▸ | AURKA | O14965 | 3/20 | 0.62 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.62 |
| ▸ | RET | P07949 | 2/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.62 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.62 |
| ▸ | FLT3 | P36888 | 2/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | FGR | P09769 | 1/20 | 0.62 |
| ▸ | FLT4 | P35916 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 1/20 | 0.62 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.62 |
| ▸ | SIK1 | P57059 | 1/20 | 0.62 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.62 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | STK10 | O94804 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2161006 | 1.00 | JAK2 (0.70) | JAK2JAK3JAK1AURKANTRK1 | |
| SCHEMBL2161030 | 0.88 | JAK2 (0.54) | JAK2JAK3JAK1AURKANTRK1 | |
| SCHEMBL2161206 | 0.86 | JAK2 (0.53) | JAK2JAK3JAK1AURKANTRK1 | |
| SCHEMBL2160850 | 0.85 | JAK2 (0.52) | JAK2JAK3JAK1AURKANTRK1 | |
| SCHEMBL2161050 | 0.85 | JAK2 (0.53) | JAK2JAK3JAK1AURKANTRK1 | |
| SCHEMBL2161216 | 0.85 | JAK2 (0.52) | JAK2JAK3JAK1AURKANTRK1 | |
| SCHEMBL12363477 | 0.84 | JAK2 (0.70) | JAK2JAK3JAK1AURKANTRK1 | |
| SCHEMBL13494394 | 0.84 | JAK2 (0.77) | JAK2JAK3JAK1AURKANTRK1 | |
| SCHEMBL2161052 | 0.84 | JAK2 (0.50) | JAK2JAK3JAK1AURKANTRK1 | |
| SCHEMBL1396179 | 0.83 | JAK2 (0.50) | JAK2JAK3JAK1AURKANTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2288602-A1 | TRICYCLIC 2,4-DIAMIN0-L,3,5-TRIAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF CANCER AND MYELOPROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2011-03-02 | — | — | EP | disclosed |
| WO-2009150462-A1 | TRICYCLIC 2,4-DIAMIN0-L,3,5-TRIAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF CANCER AND MYELOPROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2009-12-17 | — | — | WO | disclosed |