Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL98891 | 0.84 | FGFR1 (0.35) | FGFR1FGFR4SLC22A12 | |
| SCHEMBL18583995 | 0.83 | FGFR1 (0.35) | FGFR1FGFR4SLC22A12NOTUM | |
| SCHEMBL18593997 | 0.78 | FGFR1 (0.35) | FGFR1FGFR4SLC22A12NOTUM | |
| SCHEMBL10388320 | 0.77 | TSHR (0.40) | FGFR1FGFR4SLC22A12NOTUM | |
| SCHEMBL29982155 | 0.76 | FGFR1 (0.34) | FGFR1FGFR4SLC22A12 | |
| SCHEMBL3003619 | 0.71 | NOTUM (0.43) | FGFR1FGFR4NOTUM | |
| SCHEMBL31291523 | 0.71 | NOTUM (0.43) | FGFR1FGFR4NOTUM | |
| SCHEMBL31720885 | 0.70 | SLC22A12 (0.41) | FGFR1FGFR4SLC22A12NOTUM | |
| SCHEMBL1897615 | 0.70 | SLC22A12 (0.41) | FGFR1FGFR4SLC22A12NOTUM | |
| SCHEMBL4255524 | 0.70 | SLC22A12 (0.41) | FGFR1FGFR4SLC22A12NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2288610-A1 | AZETIDINE AND CYCLOBUTANE DERIVATIVES AS JAK INHIBITORS | Incyte Corporation (US) | 2011-03-02 | — | — | EP | disclosed |
| WO-2009114512-A1 | AZETIDINE AND CYCLOBUTANE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2009-09-17 | — | — | WO | disclosed |