Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 10/20 | 0.57 |
| ▸ | AXL | P30530 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12780858 | 0.85 | FLT3 (0.66) | FLT3AXLAURKAJAK2KIT | |
| SCHEMBL12781033 | 0.78 | FLT3 (0.58) | FLT3AXLAURKAJAK2KIT | |
| SCHEMBL4036749 | 0.73 | FLT3 (1.00) | FLT3AXLAURKAJAK2KIT | |
| SCHEMBL4038405 | 0.73 | AXL (0.64) | FLT3AXLAURKAJAK2KIT | |
| SCHEMBL4047467 | 0.72 | FLT3 (0.80) | FLT3AXLAURKAJAK2KIT | |
| SCHEMBL4038683 | 0.72 | FLT3 (0.61) | FLT3AXLAURKAJAK2KIT | |
| SCHEMBL12781032 | 0.71 | FLT3 (0.60) | FLT3AXLAURKAJAK2KIT | |
| SCHEMBL4039143 | 0.70 | FLT3 (0.80) | FLT3AXLAURKAJAK2KIT | |
| SCHEMBL4040345 | 0.70 | AXL (1.00) | FLT3AXLAURKAJAK2KIT | |
| SCHEMBL12780903 | 0.69 | FLT3 (0.67) | FLT3AXLAURKAJAK2KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562589-B1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2009-01-07 | — | — | EP | disclosed |