Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.41 |
| ▸ | JAK1 | P23458 | 13/20 | 0.41 |
| ▸ | JAK3 | P52333 | 8/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | CIT | O14578 | 1/20 | 0.40 |
| ▸ | GAK | O14976 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ULK1 | O75385 | 1/20 | 0.40 |
| ▸ | PRKCB | P05771 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | MARK3 | P27448 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2110159 | 0.91 | JAK2 (0.42) | JAK2JAK1JAK3AXLCIT | |
| SCHEMBL871972 | 0.89 | JAK2 (0.44) | JAK2JAK1JAK3AXLCIT | |
| SCHEMBL1396245 | 0.88 | JAK2 (0.40) | JAK2JAK1JAK3AXLCIT | |
| SCHEMBL871761 | 0.88 | JAK2 (0.41) | JAK2JAK1JAK3AXLCIT | |
| SCHEMBL6126928 | 0.87 | JAK2 (0.44) | JAK2JAK1JAK3AXLCIT | |
| SCHEMBL100440 | 0.87 | JAK2 (0.43) | JAK2JAK1JAK3CITGAK | |
| SCHEMBL1396452 | 0.87 | JAK2 (0.40) | JAK2JAK1JAK3AXLCIT | |
| SCHEMBL2109774 | 0.87 | JAK2 (0.41) | JAK2JAK1JAK3AXLCIT | |
| SCHEMBL10222872 | 0.87 | JAK2 (0.44) | JAK2JAK1JAK3AXLCIT | |
| SCHEMBL1396196 | 0.86 | JAK2 (0.45) | JAK2JAK1JAK3AXLCIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2288610-A1 | AZETIDINE AND CYCLOBUTANE DERIVATIVES AS JAK INHIBITORS | Incyte Corporation (US) | 2011-03-02 | — | — | EP | disclosed |
| WO-2009114512-A1 | AZETIDINE AND CYCLOBUTANE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2009-09-17 | — | — | WO | disclosed |