Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 11/20 | 0.51 |
| ▸ | TTK | P33981 | 5/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 9/20 | 0.47 |
| ▸ | ITK | Q08881 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.44 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1460555 | 0.90 | LRRK2 (0.53) | AURKATTKAURKBITKMAP2K4 | |
| SCHEMBL1461855 | 0.87 | AURKA (0.49) | AURKATTKAURKBITKMAPK1 | |
| SCHEMBL1460552 | 0.87 | MAPK1 (0.54) | AURKATTKAURKBITKMAPK1 | |
| SCHEMBL4014552 | 0.87 | TTK (0.56) | AURKATTKAURKBITKMAPK1 | |
| SCHEMBL6297928 | 0.87 | TTK (0.59) | AURKATTKAURKBITKMAP2K7 | |
| SCHEMBL1459783 | 0.86 | MAP2K4 (0.55) | AURKATTKAURKBITKMAP2K7 | |
| SCHEMBL1459746 | 0.86 | AURKA (0.50) | AURKATTKAURKBITKMAPK1 | |
| SCHEMBL1460705 | 0.86 | AURKA (0.50) | AURKATTKAURKBITKMAPK1 | |
| SCHEMBL1460608 | 0.86 | AURKA (0.52) | AURKATTKAURKBITKMAPK1 | |
| SCHEMBL1461791 | 0.86 | TTK (0.53) | AURKATTKAURKBITKMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7473701-B2 | Substituted indazoles, compositions containing them, method of production and use | AVENTIS PHARMA S.A. (FR) | 2009-01-06 | — | — | US | disclosed |