Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11544508 | 0.80 | SRC (0.62) | SRCBRAFKDRHPGDRIPK2 | |
| SCHEMBL2546507 | 0.77 | HPGD (0.71) | SRCBRAFKDRHPGDRIPK2 | |
| SCHEMBL15568452 | 0.77 | POLB (0.44) | HPGDKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL10568444 | 0.77 | SRC (0.56) | SRCBRAFKDRHPGDRIPK2 | |
| SCHEMBL2545006 | 0.73 | GAA (0.56) | SRCBRAFKDRHPGDRIPK2 | |
| SCHEMBL13974570 | 0.73 | HPGD (0.58) | SRCBRAFKDRHPGDRIPK2 | |
| SCHEMBL31623412 | 0.73 | CYP2C9 (0.38) | HPGDKMT2AMEN1ALDH1A1MAPK14 | |
| SCHEMBL16344251 | 0.72 | POLB (0.50) | HPGDKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL13860340 | 0.72 | GAA (0.57) | HPGDKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL14833703 | 0.71 | SRC (1.00) | SRCBRAFKDRHPGDRIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012158413-A2 | PYRROLIDINYL UREA AND PYRROLIDINYL THIOUREA COMPOUNDS AS TRKA KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2012-11-22 | — | — | WO | disclosed |