Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | ASIC1 | P78348 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13975008 | 0.85 | MAPT (0.63) | MAPTRAB9APOLBGPR142GRM5 | |
| SCHEMBL5333233 | 0.79 | HDAC3 (0.55) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL5303048 | 0.76 | GRM5 (0.54) | MAPTRAB9AHDAC3HDAC4HDAC1 | |
| SCHEMBL10112053 | 0.74 | SMN1; SMN2 (0.59) | MAPTRAB9AHDAC3HDAC4HDAC1 | |
| SCHEMBL13539293 | 0.74 | HDAC3 (0.56) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL1414029 | 0.74 | HDAC3 (0.56) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL30722849 | 0.73 | HDAC3 (0.56) | MAPTRAB9AHDAC3HDAC4HDAC1 | |
| SCHEMBL31057128 | 0.73 | MAPT (0.49) | MAPTRAB9AHDAC3HDAC4HDAC1 | |
| SCHEMBL23657670 | 0.73 | MAPT (0.52) | MAPTRAB9APOLBGRM5ALDH1A1 | |
| SCHEMBL28014536 | 0.73 | HDAC3 (0.55) | MAPTHDAC3HDAC4HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012158413-A2 | PYRROLIDINYL UREA AND PYRROLIDINYL THIOUREA COMPOUNDS AS TRKA KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2012-11-22 | — | — | WO | disclosed |