Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1397967 | 0.93 | HRH3 (0.80) | HRH3CYP2D6 | |
| SCHEMBL1397991 | 0.93 | HRH3 (0.80) | HRH3CYP2D6 | |
| SCHEMBL1397927 | 0.93 | HRH3 (0.77) | HRH3CYP2D6 | |
| SCHEMBL1397949 | 0.92 | HRH3 (0.85) | HRH3CYP2D6 | |
| SCHEMBL1397975 | 0.92 | HRH3 (0.79) | HRH3CYP2D6 | |
| SCHEMBL1397922 | 0.91 | HRH3 (0.77) | HRH3CYP2D6 | |
| SCHEMBL1397926 | 0.91 | HRH3 (0.74) | HRH3CYP2D6 | |
| SCHEMBL1397969 | 0.91 | HRH3 (0.77) | HRH3CYP2D6 | |
| SCHEMBL1397968 | 0.90 | HRH3 (0.76) | HRH3CYP2D6 | |
| SCHEMBL1397924 | 0.90 | HRH3 (0.78) | HRH3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957479-B1 | 1,5-SUBSTITUTED INDOL-2-YL AMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-03-02 | — | — | EP | claimed |
| US-7745479-B2 | 1,5-substituted indol-2-yl amide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-06-29 | — | — | US | claimed |
| EP-1957479-A2 | 1,5-SUBSTITUTED INDOL-2-YL AMIDE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-08-20 | — | — | EP | claimed |
| WO-2007062999-A2 | 1,5-SUBSTITUTED INDOL-2-YL AMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-07 | — | — | WO | claimed |
| US-20070123515-A1 | 1,5-Substituted indol-2-yl amide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-31 | — | — | US | claimed |
| EP-1957479-B1 | 1,5-SUBSTITUTED INDOL-2-YL AMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-03-02 | — | — | EP | disclosed |
| US-7745479-B2 | 1,5-substituted indol-2-yl amide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-06-29 | — | — | US | disclosed |
| EP-1957479-A2 | 1,5-SUBSTITUTED INDOL-2-YL AMIDE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007062999-A2 | 1,5-SUBSTITUTED INDOL-2-YL AMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-07 | — | — | WO | disclosed |
| US-20070123515-A1 | 1,5-Substituted indol-2-yl amide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123515-A1 | 1,5-Substituted indol-2-yl amide derivatives | HRH4, HRH3, HRH2 | HRH3 2/4885CYP2D6 591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.