Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1398089 | 0.99 | NPC1 (0.38) | NPC1HPGDRAB9ASMN1; SMN2CRBN | |
| SCHEMBL1398054 | 0.88 | CRBN (0.44) | NPC1HPGDRAB9ASMN1; SMN2CRBN | |
| SCHEMBL1398165 | 0.83 | DDB1 (0.32) | CRBNDDB1 | |
| Bromide SCHEMBL1398080 | 0.82 | DDB1 (0.32) | CRBNDDB1 | |
| SCHEMBL5162159 | 0.79 | CRBN (0.58) | CRBNTDP1DDB1ALDH1A1 | |
| SCHEMBL1398103 | 0.76 | NPC1 (0.40) | NPC1HPGDRAB9ASMN1; SMN2CRBN | |
| SCHEMBL1398035 | 0.73 | CRBN (0.38) | RAB9ACRBNTDP1DDB1ALDH1A1 | |
| SCHEMBL1398110 | 0.72 | TSHR (0.40) | NPC1HPGDRAB9ASMN1; SMN2PDE3B | |
| SCHEMBL1398031 | 0.72 | PDE3B (0.45) | RAB9ACRBNPDE3BPDE3AGAA | |
| SCHEMBL1398092 | 0.72 | CRBN (0.44) | RAB9ACRBNTDP1DDB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957481-B1 | PYRROLIDIN(THI)ONES HETEROCYCLICALLY SUBSTITUTED IN 3-POSITION | GRUENENTHAL GMBH (DE) | 2011-03-02 | — | — | EP | claimed |