Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 2/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25053007 | 1.00 | KDM4E (0.53) | KDM4EALDH1A1CYP1A2HPGDHSD17B10 | |
| SCHEMBL17432077 | 0.77 | IDO1 (0.50) | KDM4EALDH1A1CYP1A2HPGDHSD17B10 | |
| SCHEMBL7920682 | 0.74 | PTPN7 (0.37) | KDM4EALDH1A1CYP1A2HPGDHSD17B10 | |
| SCHEMBL27460526 | 0.74 | KDM4E (0.40) | KDM4EALDH1A1CYP1A2HPGDHSD17B10 | |
| SCHEMBL29070744 | 0.74 | HTR2C (0.40) | KDM4EALDH1A1CYP1A2HPGDHSD17B10 | |
| SCHEMBL15508323 | 0.74 | HTR2C (0.40) | KDM4EALDH1A1CYP1A2HPGDHSD17B10 | |
| SCHEMBL30570965 | 0.74 | HTR2C (0.40) | KDM4EALDH1A1CYP1A2HPGDHSD17B10 | |
| SCHEMBL29004248 | 0.74 | HTR2C (0.40) | KDM4EALDH1A1CYP1A2HPGDHSD17B10 | |
| SCHEMBL29004245 | 0.74 | HTR2C (0.40) | KDM4EALDH1A1CYP1A2HPGDHSD17B10 | |
| SCHEMBL23063003 | 0.73 | BRD4 (0.42) | KDM4EALDH1A1CYP1A2HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008152013-A1 | INDOLINONE DERIVATIVES AND THEIR USE IN TREATING DISEASE-STATES SUCH AS CANCER | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-12-18 | — | — | WO | disclosed |