Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 14/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13984090 | 0.92 | CHEK1 (0.39) | AURKAEGFRAURKBCHEK1 | |
| SCHEMBL14463861 | 0.91 | AURKA (0.51) | AURKAEGFRAURKBCHEK1 | |
| SCHEMBL12409703 | 0.88 | AURKA (0.46) | AURKAEGFRAURKBCHEK1POLB | |
| SCHEMBL12409723 | 0.79 | CHEK1 (0.40) | AURKAEGFRAURKBCHEK1 | |
| SCHEMBL4533435 | 0.79 | AURKA (0.52) | AURKAEGFRAURKBCHEK1 | |
| SCHEMBL13983968 | 0.79 | AURKA (0.38) | AURKAEGFRAURKBCHEK1 | |
| SCHEMBL13983979 | 0.74 | AURKA (0.34) | AURKAEGFRAURKBCHEK1 | |
| SCHEMBL14463686 | 0.74 | AURKA (0.36) | AURKAEGFRAURKBCHEK1 | |
| SCHEMBL14021437 | 0.73 | AURKA (0.55) | AURKAEGFRAURKBCHEK1 | |
| SCHEMBL14021557 | 0.73 | AURKA (0.55) | AURKAEGFRAURKBCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008155016-A1 | SUBSTITUTED FUROPYRIMIDINES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-12-24 | — | — | WO | disclosed |