Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.60 |
| ▸ | S1PR3 | Q99500 | 10/20 | 0.58 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1398440 | 0.86 | S1PR1 (0.65) | S1PR1S1PR3S1PR5KCNH2 | |
| SCHEMBL1398414 | 0.84 | S1PR1 (0.67) | S1PR1S1PR3S1PR5KCNH2 | |
| SCHEMBL12808923 | 0.83 | S1PR1 (0.56) | S1PR1S1PR3S1PR5KCNH2 | |
| SCHEMBL1398442 | 0.83 | S1PR1 (0.67) | S1PR1S1PR3S1PR5KCNH2 | |
| SCHEMBL1398449 | 0.83 | S1PR1 (0.58) | S1PR1S1PR3S1PR5KCNH2 | |
| SCHEMBL1398408 | 0.82 | S1PR1 (0.58) | S1PR1S1PR3S1PR5KCNH2 | |
| SCHEMBL1398553 | 0.82 | S1PR1 (0.62) | S1PR1S1PR3S1PR5KCNH2 | |
| SCHEMBL1398515 | 0.81 | S1PR1 (0.78) | S1PR1S1PR3S1PR5KCNH2 | |
| SCHEMBL1398452 | 0.81 | S1PR1 (0.54) | S1PR1S1PR3S1PR5KCNH2 | |
| SCHEMBL1398682 | 0.81 | S1PR1 (0.60) | S1PR1S1PR3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137181-B1 | OXADIAZOLE SUBSTITUTED INDAZOLE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE (S1P) AGONISTS | GLAXO GROUP LTD (GB) | 2011-03-02 | — | — | EP | disclosed |