Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 13/20 | 0.89 |
| ▸ | PLK4 | O00444 | 4/20 | 0.89 |
| ▸ | RET | P07949 | 4/20 | 0.89 |
| ▸ | FLT3 | P36888 | 4/20 | 0.89 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.89 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.89 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.89 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.89 |
| ▸ | AURKA | O14965 | 3/20 | 0.89 |
| ▸ | MST1R | Q04912 | 3/20 | 0.89 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.89 |
| ▸ | STK16 | O75716 | 2/20 | 0.89 |
| ▸ | TNK1 | Q13470 | 2/20 | 0.89 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.89 |
| ▸ | ADCK1 | Q86TW2 | 2/20 | 0.89 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.89 |
| ▸ | NEK9 | Q8TD19 | 2/20 | 0.89 |
| ▸ | IRAK3 | Q9Y616 | 2/20 | 0.89 |
| ▸ | LATS1 | O95835 | 1/20 | 0.89 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fostamatinib SCHEMBL29351337 | 0.94 | SYK (1.00) | SYKPLK4RETFLT3MAPK8 | |
| Fostamatinib SCHEMBL1201371 | 0.94 | SYK (1.00) | SYKPLK4RETFLT3MAPK8 | |
| SCHEMBL13451994 | 0.94 | SYK (0.91) | SYKPLK4RETFLT3MAPK8 | |
| Fostamatinib SCHEMBL22164570 | 0.94 | SYK (0.99) | SYKPLK4RETFLT3MAPK8 | |
| Fostamatinib SCHEMBL16820327 | 0.94 | SYK (0.99) | SYKPLK4RETFLT3MAPK8 | |
| SCHEMBL15317969 | 0.93 | SYK (0.85) | SYKPLK4RETFLT3MAPK8 | |
| Fostamatinib SCHEMBL28519986 | 0.93 | SYK (0.97) | SYKPLK4RETFLT3MAPK8 | |
| SCHEMBL14751923 | 0.93 | SYK (0.87) | SYKPLK4RETFLT3MAPK8 | |
| SCHEMBL16820329 | 0.93 | SYK (0.89) | SYKPLK4RETFLT3MAPK8 | |
| Fostamatinib SCHEMBL29219528 | 0.92 | SYK (0.91) | SYKPLK4RETFLT3MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9695204-B2 | Pharmaceutical process and intermediates | RIGEL PHARMACEUTICALS, INC. (US) | 2017-07-04 | — | — | US | disclosed |
| WO-2009003136-A1 | SUBSTITUTED PYRIMIDINE-2, 4 -DIAMINES FOR TREATING CELL PROLIFERATIVE DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2008-12-31 | — | — | WO | disclosed |
| WO-2008064274-A1 | PRODRUG SALTS OF 2, 4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2008-05-29 | — | — | WO | disclosed |