Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 17/20 | 0.60 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.49 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1980729 | 0.95 | S1PR1 (0.64) | S1PR1S1PR3S1PR5CYP2C9MAP4K4 | |
| SCHEMBL12808913 | 0.91 | S1PR1 (0.66) | S1PR1S1PR3S1PR5CYP2C9MAP4K4 | |
| SCHEMBL1398451 | 0.90 | S1PR1 (0.75) | S1PR1S1PR3S1PR5CYP2C9MAP4K4 | |
| Hydrochloric Acid SCHEMBL1398410 | 0.90 | S1PR1 (0.65) | S1PR1S1PR3S1PR5CYP2C9MAP4K4 | |
| SCHEMBL12600925 | 0.90 | S1PR1 (0.52) | S1PR1S1PR3S1PR5 | |
| SCHEMBL12600927 | 0.89 | S1PR1 (0.54) | S1PR1S1PR3S1PR5CYP2C9 | |
| SCHEMBL12601089 | 0.89 | S1PR1 (0.54) | S1PR1S1PR3S1PR5CYP2C9 | |
| SCHEMBL2053882 | 0.88 | S1PR1 (0.52) | S1PR1S1PR3S1PR5CYP2C9 | |
| SCHEMBL2007735 | 0.87 | S1PR1 (0.55) | S1PR1S1PR3S1PR5CYP2C9 | |
| SCHEMBL1981765 | 0.87 | S1PR1 (0.52) | S1PR1S1PR3S1PR5CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324254-B2 | Oxadiazole substituted indazole derivatives for use as sphingosine 1-phosphate (S1P) agonists | GLAXO GROUP LIMITED (GB) | 2012-12-04 | — | — | US | disclosed |
| US-8324254-B2 | Oxadiazole substituted indazole derivatives for use as sphingosine 1-phosphate (S1P) agonists | GLAXO GROUP LIMITED (GB) | 2012-12-04 | — | — | US | disclosed |
| EP-2137181-B1 | OXADIAZOLE SUBSTITUTED INDAZOLE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE (S1P) AGONISTS | GLAXO GROUP LTD (GB) | 2011-03-02 | — | — | EP | disclosed |
| US-20100113528-A1 | OXADIAZOLE SUBSTITUTED INDAZOLE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE (S1P) AGONISTS | GLAXO GROUP LIMITED | 2010-05-06 | — | — | US | disclosed |
| US-20100113528-A1 | OXADIAZOLE SUBSTITUTED INDAZOLE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE (S1P) AGONISTS | GLAXO GROUP LIMITED | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113528-A1 | OXADIAZOLE SUBSTITUTED INDAZOLE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE (S1P) AGONISTS | S1PR1, S1PR3, S1PR2 | S1PR1 1/4885S1PR3 2/4885S1PR5 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.