Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 16/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | NMT1 | P30419 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211684 | 0.93 | AURKA (0.48) | AURKAKCNH2NMT1FLT3 | |
| SCHEMBL211070 | 0.90 | AURKA (0.56) | AURKAKCNH2FLT3 | |
| SCHEMBL208033 | 0.87 | AURKA (0.49) | AURKAKCNH2 | |
| SCHEMBL4754651 | 0.86 | AURKA (0.48) | AURKAKCNH2NMT1FLT3DRD2 | |
| SCHEMBL13985589 | 0.85 | AURKA (0.42) | AURKAKCNH2FGFR1FGFR2FGFR4 | |
| SCHEMBL14495704 | 0.84 | AURKA (0.43) | AURKAKCNH2FLT3 | |
| SCHEMBL211835 | 0.84 | AURKA (0.56) | AURKA | |
| SCHEMBL207979 | 0.83 | AURKA (0.43) | AURKAKCNH2FGFR1FGFR2FGFR4 | |
| SCHEMBL209500 | 0.83 | AURKA (0.58) | AURKAKCNH2FLT3 | |
| SCHEMBL210154 | 0.82 | AURKA (0.57) | AURKAKCNH2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001021-A1 | IMIDAZOPYRIDINE DERIVATIVES USEFUL AS ENZYME INHIBITORS FOR THE TREATMENT OF CELL PROLIFERATIVE AND AUTOIMMUNE DISEASES | CHROMA THERAPEUTICS LTD. (GB) | 2008-12-31 | — | — | WO | disclosed |