Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 7/20 | 0.37 |
| ▸ | RECQL | P46063 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | XBP1 | P17861 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13981339 | 1.00 | CA12 (0.39) | CA12CA14CA1CA2CA7 | |
| SCHEMBL13981338 | 1.00 | CA12 (0.39) | CA12CA14CA1CA2CA7 | |
| SCHEMBL17922694 | 0.84 | DPP4 (0.42) | CA12CA14CA1CA2CA7 | |
| SCHEMBL20789026 | 0.84 | DPP4 (0.42) | CA12CA14CA1CA2CA7 | |
| SCHEMBL22064364 | 0.84 | DPP4 (0.42) | CA12CA14CA1CA2CA7 | |
| SCHEMBL25122324 | 0.84 | DPP4 (0.42) | CA12CA14CA1CA2CA7 | |
| SCHEMBL4528321 | 0.84 | DPP4 (0.42) | CA12CA14CA1CA2CA7 | |
| SCHEMBL17570947 | 0.84 | DPP4 (0.42) | CA12CA14CA1CA2CA7 | |
| SCHEMBL22342115 | 0.82 | NPSR1 (0.36) | CA12CA14CA1CA2CA7 | |
| SCHEMBL22342114 | 0.82 | NPSR1 (0.36) | CA12CA14CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7468371-B2 | Tricyclic pyrazole kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-12-23 | — | — | US | disclosed |