Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 18/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL210154 | 0.90 | AURKA (0.57) | AURKAKCNH2FLT3 | |
| SCHEMBL211070 | 0.90 | AURKA (0.56) | AURKAKCNH2FLT3 | |
| SCHEMBL207811 | 0.88 | AURKA (0.51) | AURKAKCNH2FLT3KMT2A | |
| SCHEMBL211315 | 0.85 | AURKA (0.46) | AURKAKCNH2FLT3 | |
| SCHEMBL209820 | 0.85 | AURKA (0.58) | AURKAKCNH2FLT3 | |
| SCHEMBL211868 | 0.85 | AURKA (0.48) | AURKAKCNH2FLT3CHRM4KMT2A | |
| SCHEMBL13985587 | 0.84 | AURKA (0.57) | AURKAKCNH2FLT3 | |
| SCHEMBL209180 | 0.84 | AURKA (0.58) | AURKAKCNH2FLT3 | |
| SCHEMBL211835 | 0.83 | AURKA (0.56) | AURKA | |
| SCHEMBL211867 | 0.83 | AURKA (0.42) | AURKAKCNH2FLT3CHRM4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001021-A1 | IMIDAZOPYRIDINE DERIVATIVES USEFUL AS ENZYME INHIBITORS FOR THE TREATMENT OF CELL PROLIFERATIVE AND AUTOIMMUNE DISEASES | CHROMA THERAPEUTICS LTD. (GB) | 2008-12-31 | — | — | WO | disclosed |