Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 13/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | BCR | P11274 | 2/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.49 |
| ▸ | AURKA | O14965 | 5/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.49 |
| ▸ | SGK1 | O00141 | 2/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13986221 | 0.87 | PDPK1 (0.66) | JAK2PDPK1ABL1BCRTGFBR1 | |
| SCHEMBL6478485 | 0.84 | JAK2 (0.66) | JAK2PDPK1ABL1BCRFGFR1 | |
| SCHEMBL13524482 | 0.83 | JAK2 (0.50) | JAK2PDPK1ABL1BCRFGFR1 | |
| SCHEMBL13525176 | 0.82 | PDPK1 (0.65) | JAK2PDPK1ABL1BCRTGFBR1 | |
| SCHEMBL13986219 | 0.80 | JAK2 (0.56) | JAK2PDPK1ABL1BCRFGFR1 | |
| SCHEMBL13525152 | 0.80 | PDPK1 (0.57) | JAK2PDPK1ABL1BCRTGFBR1 | |
| SCHEMBL6479941 | 0.79 | JAK2 (0.72) | JAK2PDPK1ABL1BCRTGFBR1 | |
| SCHEMBL4491663 | 0.78 | PDPK1 (0.71) | JAK2PDPK1ABL1BCRTGFBR1 | |
| SCHEMBL13524475 | 0.78 | JAK2 (0.54) | JAK2PDPK1ABL1BCRTGFBR1 | |
| SCHEMBL91579 | 0.77 | PDPK1 (0.55) | JAK2PDPK1FGFR1TGFBR1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459564-B2 | Substituted biaryl compounds as factor XIa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-02 | — | — | US | disclosed |