Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | ACR | P10323 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13986950 | 0.90 | GSK3B (0.59) | GSK3BHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4851367 | 0.87 | GSK3B (0.61) | GSK3BHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4857434 | 0.85 | GSK3B (0.59) | GSK3BHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4855836 | 0.85 | GSK3B (0.54) | GSK3BHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13986964 | 0.83 | MAPK1 (0.58) | GSK3BHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13986993 | 0.82 | GSK3B (0.64) | GSK3BHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13986974 | 0.82 | GSK3B (0.58) | GSK3BHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13986955 | 0.82 | GSK3B (0.58) | GSK3BHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13986939 | 0.81 | GSK3B (0.59) | GSK3BHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13986997 | 0.79 | GSK3B (0.58) | GSK3BHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |