Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.48 |
| ▸ | CLK2 | P49760 | 2/20 | 0.48 |
| ▸ | CLK3 | P49761 | 2/20 | 0.48 |
| ▸ | WNT1 | P04628 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.47 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14348307 | 1.00 | DYRK1A (0.48) | DYRK1ACLK2CLK3WNT1GSK3B | |
| Trifluoroacetic Acid SCHEMBL5667546 | 0.94 | DYRK1A (0.46) | DYRK1ACLK2CLK3WNT1GSK3B | |
| SCHEMBL10063159 | 0.83 | ITK (0.51) | DYRK1ACLK2CLK3WNT1CACNA1B | |
| SCHEMBL15116263 | 0.83 | ITK (0.51) | DYRK1ACLK2CLK3WNT1CACNA1B | |
| SCHEMBL5232508 | 0.79 | MAPK8 (0.55) | DYRK1AWNT1GSK3BMAPK8KCNH2 | |
| SCHEMBL4854577 | 0.79 | GSK3B (0.49) | DYRK1AWNT1GSK3BMAPK8ROCK2 | |
| SCHEMBL5236116 | 0.78 | GSK3B (0.52) | DYRK1ACLK2GSK3BSMN1; SMN2NPSR1 | |
| SCHEMBL5233639 | 0.78 | GSK3B (0.52) | DYRK1ACLK2WNT1GSK3BSMN1; SMN2 | |
| SCHEMBL13987020 | 0.77 | GSK3B (0.48) | DYRK1AGSK3BSMN1; SMN2MAPK8ROCK2 | |
| SCHEMBL13986941 | 0.77 | MERTK (0.47) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |