Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 5/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | SELP | P16109 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13987026 | 0.79 | GSK3B (0.52) | GSK3BCXCR4KMT2AKDM4EMAPK1 | |
| SCHEMBL2947276 | 0.76 | GSK3B (0.52) | GSK3BAKT3PDPK1CDC7BRAF | |
| SCHEMBL4853882 | 0.75 | GSK3B (0.55) | GSK3BKMT2AAKT3 | |
| SCHEMBL2946867 | 0.75 | GSK3B (0.49) | GSK3BKMT2AKDM4EPDPK1 | |
| SCHEMBL13987017 | 0.75 | GSK3B (0.67) | GSK3BKDM4ETYRO3 | |
| SCHEMBL13987018 | 0.73 | GSK3B (0.53) | GSK3BCXCR4KMT2AMAPK1PARP1 | |
| SCHEMBL13987027 | 0.72 | GSK3B (1.00) | GSK3BKDM4ETYRO3CNR2 | |
| SCHEMBL13987029 | 0.71 | GSK3B (0.65) | GSK3BAKT3PARP1CNR2 | |
| SCHEMBL4857179 | 0.71 | GSK3B (0.65) | GSK3BPDPK1CDC7 | |
| SCHEMBL4856852 | 0.71 | GSK3B (0.66) | GSK3BTYRO3PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |