Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 15/20 | 0.51 |
| ▸ | PLK3 | Q9H4B4 | 9/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.51 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | NEK2 | P51955 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14047822 | 0.86 | PLK1 (0.50) | PLK1PLK3CYP2C9IKBKECDK2 | |
| SCHEMBL14047659 | 0.85 | PLK1 (0.56) | PLK1PLK3CYP2C9IKBKECDK2 | |
| SCHEMBL13462810 | 0.84 | IKBKE (0.49) | PLK1PLK3CYP2C9IKBKECDK2 | |
| SCHEMBL14047658 | 0.83 | PLK1 (0.55) | PLK1PLK3CYP2C9IKBKECDK2 | |
| SCHEMBL14047896 | 0.82 | PLK1 (0.51) | PLK1PLK3CYP2C9IKBKECDK2 | |
| SCHEMBL14047895 | 0.82 | PLK1 (0.67) | PLK1PLK3CYP2C9IKBKECDK2 | |
| SCHEMBL13632297 | 0.81 | PLK1 (0.49) | PLK1PLK3CYP2C9IKBKECDK2 | |
| SCHEMBL13632188 | 0.81 | PLK1 (0.48) | PLK1PLK3CYP2C9IKBKECDK2 | |
| SCHEMBL14047802 | 0.79 | PLK1 (0.54) | PLK1PLK3CYP2C9IKBKECDK2 | |
| SCHEMBL14047661 | 0.78 | PLK1 (0.56) | PLK1PLK3CYP2C9IKBKECDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465807-B2 | Process for preparing benzimidazole thiophenes | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-16 | — | — | US | disclosed |