SCHEMBL1399146

SCHEMBL1399146

O=C1C=CCC1O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7824333 0.76
SCHEMBL1986587 0.74
SCHEMBL13248855 0.67 MAPT (0.31)
SCHEMBL16368529 0.67
SCHEMBL6902631 0.67
SCHEMBL12154579 0.67
SCHEMBL8228480 0.67
SCHEMBL12330075 0.67
SCHEMBL1072882 0.67
SCHEMBL3630845 0.65

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106431870-B A kind of preparation method of 5- hydroxyl -2- cyclopentenone compounds 兰州大学 2019-04-09 CN claimed
CN-106431870-A Preparation method of 5-hydroxy-2-cyclopentenone compound 兰州大学 2017-02-22 CN claimed
US-7683068-B2 Hydroisoindoline tachykinin receptor antagonists MERCK SHARP & DOHME CORP. (US) 2010-03-23 US claimed
US-7652058-B2 Octahydropyrano[3,4-C]pyrrole tachykinin receptor antagonists MERCK SHARP & DOHME CORP. (US) 2010-01-26 US claimed
EP-1827420-A4 OCTAHYDROPYRANO[3,4-C]PYRROLE TACHYKININ RECEPTOR ANTAGONISTS MERCK & CO INC (US) 2009-03-04 EP claimed
EP-1546150-B1 PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES AMURA THERAPEUTICS LTD (GB) 2009-03-04 EP claimed
US-20090054462-A1 Hydroisoindoline tachykinin receptor antagonists MERCK SHARP & DOHME CORP. 2009-02-26 US claimed
US-20080280966-A1 Hydroisoindoline Tachykinin Receptor Antagonists VYNE THERAPEUTICS INC. (F/K/A MENLO THERAPEUTICS INC. AND SUCCESSOR-IN-INTEREST TO VYNE PHARMACEUTICALS LTD., F/K/A FOAMIX PHARMACEUTICALS LTD.) 2008-11-13 US claimed
US-20080108689-A1 Octahydropyrano[3,4-C]Pyrrole Tachykinin Receptor Antagonists MERCK SHARP & DOHME CORP. 2008-05-08 US claimed
EP-1898905-A2 HYDROISOINDOLINE TACHYKININ RECEPTOR ANTAGONISTS Merck & Co., Inc. (US) 2008-03-19 EP claimed
EP-1827420-A2 OCTAHYDROPYRANO[3,4-C]PYRROLE TACHYKININ RECEPTOR ANTAGONISTS Merck & Co., Inc. (US) 2007-09-05 EP claimed
US-7217731-B2 Hydroisoindoline tachykinin receptor antagonists MERCK & CO., INC. (US) 2007-05-15 US claimed
WO-2007002457-A2 HYDROISOINDOLINE TACHYKININ RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 2007-01-04 WO claimed
EP-1711465-A1 HYDROISOINDOLINE TACHYKININ RECEPTOR ANTAGONISTS Merck & Co., Inc. (US) 2006-10-18 EP claimed
WO-2006065711-A2 OCTAHYDROPYRANO[3,4-C]PYRROLE TACHYKININ RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 2006-06-22 WO claimed
WO-2005073191-A1 HYDROISOINDOLINE TACHYKININ RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 2005-08-11 WO claimed
US-20050165083-A1 Hydroisoindoline tachykinin receptor antagonists VYNE THERAPEUTICS INC. (F/K/A MENLO THERAPEUTICS INC. AND SUCCESSOR-IN-INTEREST TO VYNE PHARMACEUTICALS LTD., F/K/A FOAMIX PHARMACEUTICALS LTD.) 2005-07-28 US claimed
EP-0115860-B1 OPTICALLY ACTIVE 4-HYDROXY-2-CYCLOPENTENONES, AND THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1988-10-12 EP claimed
US-4729953-A 4-CYCLOPENTENONE ESTER, HYDROLYSIS, ENZYME OR MICROORGANISM, REARRANGEMENTS, CATALYSTS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1988-03-08 US claimed
EP-0115860-A2 Optically active 4-hydroxy-2-cyclopentenones, and their production SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1984-08-15 EP claimed