Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 6/20 | 0.67 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.67 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.67 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.67 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14043298 | 0.84 | CDK2 (0.46) | CDK2CHEK1CCNA2CCNA1PPARA | |
| SCHEMBL12953407 | 0.84 | CDK2 (0.46) | CDK2CHEK1CCNA2CCNA1CCNE1 | |
| SCHEMBL4177549 | 0.80 | CDK2 (1.00) | CDK2CHEK1CCNA2CCNA1CSNK2A1 | |
| SCHEMBL11930889 | 0.79 | CDK2 (0.76) | CDK2CHEK1CCNA2CCNA1CSNK2A1 | |
| SCHEMBL13993120 | 0.78 | CDK2 (0.74) | CDK2CHEK1CCNA2CCNA1CSNK2A1 | |
| SCHEMBL13998533 | 0.77 | GSK3B (0.51) | CDK2CHEK1CCNA2CCNA1CCNE1 | |
| SCHEMBL13993127 | 0.76 | CHEK1 (0.63) | CDK2CHEK1CCNA2CCNA1CSNK2A1 | |
| SCHEMBL12953347 | 0.75 | CDK2 (0.73) | CDK2CHEK1CCNA2CCNA1CSNK2A1 | |
| SCHEMBL5460449 | 0.74 | CHEK1 (0.42) | CDK2CHEK1CCNA2CCNA1CCNE1 | |
| SCHEMBL7833604 | 0.74 | CDK2 (0.47) | CDK2CHEK1CCNA2CCNA1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7468372-B2 | Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2008-12-23 | — | — | US | disclosed |
| US-7468372-B2 | Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2008-12-23 | — | — | US | disclosed |