Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 7/20 | 0.55 |
| ▸ | CDK9 | P50750 | 7/20 | 0.55 |
| ▸ | KIT | P10721 | 2/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.47 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5010250 | 0.94 | KIT (0.53) | CCNT1CDK9KITMKNK1TBK1 | |
| SCHEMBL13994128 | 0.92 | CCNT1 (0.51) | CCNT1CDK9KITMKNK1TBK1 | |
| SCHEMBL5008291 | 0.91 | CCNT1 (0.51) | CCNT1CDK9KITMKNK1TBK1 | |
| SCHEMBL5008380 | 0.91 | CCNT1 (0.53) | CCNT1CDK9KITMKNK1TBK1 | |
| SCHEMBL13994074 | 0.90 | CCNT1 (0.51) | CCNT1CDK9KITMKNK1TBK1 | |
| SCHEMBL13994143 | 0.89 | CCNT1 (0.49) | CCNT1CDK9KITMKNK1TBK1 | |
| SCHEMBL13994066 | 0.89 | CCNT1 (0.49) | CCNT1CDK9KITMKNK1TBK1 | |
| SCHEMBL13994108 | 0.89 | CCNT1 (0.51) | CCNT1CDK9KITMKNK1TBK1 | |
| SCHEMBL5005409 | 0.88 | CCNT1 (0.48) | CCNT1CDK9KITMKNK1TBK1 | |
| SCHEMBL13994075 | 0.88 | CCNT1 (0.49) | CCNT1CDK9KITMKNK1TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465726-B2 | Substituted pyrrolo[2.3-B]pyridines | OSI PHARMACEUTICALS, INC. (US) | 2008-12-16 | — | — | US | disclosed |