Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 16/20 | 0.42 |
| ▸ | RIPK3 | Q9Y572 | 3/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.40 |
| ▸ | CDK9 | P50750 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5008119 | 0.94 | CCNT1 (0.40) | CCNT1CDK9 | |
| SCHEMBL5010180 | 0.89 | RIPK2 (0.45) | RIPK2RIPK3 | |
| SCHEMBL5005677 | 0.89 | RIPK2 (0.45) | RIPK2RIPK3 | |
| SCHEMBL5008365 | 0.89 | RIPK2 (0.53) | RIPK2RIPK3GAKNOD2CCNT1 | |
| SCHEMBL25799937 | 0.85 | RIPK2 (0.55) | RIPK2 | |
| SCHEMBL13994164 | 0.84 | CCNT1 (0.39) | CCNT1CDK9 | |
| SCHEMBL13994197 | 0.84 | CCNT1 (0.43) | CCNT1CDK9 | |
| SCHEMBL13994106 | 0.84 | CCNT1 (0.43) | CCNT1CDK9 | |
| SCHEMBL5004683 | 0.83 | CCNT1 (0.48) | CCNT1CDK9 | |
| SCHEMBL5001496 | 0.83 | CCNT1 (0.45) | CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465726-B2 | Substituted pyrrolo[2.3-B]pyridines | OSI PHARMACEUTICALS, INC. (US) | 2008-12-16 | — | — | US | disclosed |
| US-7465726-B2 | Substituted pyrrolo[2.3-B]pyridines | OSI PHARMACEUTICALS, INC. (US) | 2008-12-16 | — | — | US | disclosed |