Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 6/20 | 0.40 |
| ▸ | F2 | P00734 | 3/20 | 0.40 |
| ▸ | F10 | P00742 | 3/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.40 |
| ▸ | F7 | P08709 | 3/20 | 0.40 |
| ▸ | F3 | P13726 | 3/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.38 |
| ▸ | PDE4A | P27815 | 4/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.38 |
| ▸ | DDX3X | O00571 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13113647 | 0.83 | ACACB (0.42) | ACACBF2F10PRSS1PRSS2 | |
| SCHEMBL21600868 | 0.82 | HRH3 (0.43) | — | |
| SCHEMBL13994031 | 0.82 | ACACB (0.40) | ACACBF2F10PRSS1PRSS2 | |
| SCHEMBL13996516 | 0.80 | F2 (0.38) | ACACBF2F10PRSS1PRSS2 | |
| SCHEMBL13185109 | 0.80 | ACACB (0.43) | ACACBPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL11936040 | 0.79 | HRH3 (0.44) | ACACB | |
| SCHEMBL11935846 | 0.78 | IRAK4 (0.38) | ACACBF2F10PRSS1PRSS2 | |
| SCHEMBL13439257 | 0.78 | KDM4E (0.38) | ACACBF2F10PRSS1PRSS2 | |
| SCHEMBL11935514 | 0.78 | KDM4E (0.38) | ACACBF2F10PRSS1PRSS2 | |
| SCHEMBL21443397 | 0.77 | LRRK2 (0.43) | ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465726-B2 | Substituted pyrrolo[2.3-B]pyridines | OSI PHARMACEUTICALS, INC. (US) | 2008-12-16 | — | — | US | disclosed |