Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 2/20 | 0.46 |
| ▸ | CCND1 | P24385 | 2/20 | 0.46 |
| ▸ | CCND2 | P30279 | 2/20 | 0.46 |
| ▸ | CCND3 | P30281 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 12/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 5/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13998480 | 0.83 | GSK3B (0.46) | GSK3BCDK2HTR6MAPKAPK2 | |
| SCHEMBL13998473 | 0.82 | GSK3B (0.52) | GSK3BCDK2HTR6 | |
| SCHEMBL13998479 | 0.78 | GSK3B (0.47) | CDK4CCND1CCND2CCND3GSK3B | |
| SCHEMBL12953771 | 0.78 | GSK3B (0.58) | GSK3BCDK2 | |
| SCHEMBL12954010 | 0.77 | GSK3B (0.73) | GSK3BCDK2 | |
| SCHEMBL12953384 | 0.73 | GSK3B (0.40) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL13305014 | 0.73 | KDM4E (0.48) | GSK3BHTR6NPC1RAB9A | |
| SCHEMBL12953377 | 0.71 | GSK3B (0.49) | GSK3BCDK2 | |
| SCHEMBL14565205 | 0.71 | KDM4E (0.42) | HTR6NPC1RAB9A | |
| SCHEMBL12953769 | 0.69 | PDE9A (0.49) | GSK3BCDK2HTR6NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470695-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |
| US-7470695-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |
| EP-1534709-B1 | PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2007044401-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |
| US-7196092-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196092-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |