Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 16/20 | 0.46 |
| ▸ | CDK2 | P24941 | 6/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | BCL6 | P41182 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13998510 | 1.00 | GSK3B (0.46) | GSK3BCDK2MAPKAPK2CCNE1BCL6 | |
| SCHEMBL14492474 | 0.89 | BCL6 (0.38) | GSK3BCDK2CCNE1BCL6 | |
| SCHEMBL14492491 | 0.87 | TYK2 (0.38) | BCL6 | |
| SCHEMBL11930863 | 0.86 | GSK3B (0.65) | GSK3BCDK2CCNE1 | |
| SCHEMBL11930871 | 0.86 | GSK3B (0.65) | GSK3BCDK2CCNE1 | |
| SCHEMBL12952925 | 0.86 | GSK3B (0.65) | GSK3BCDK2CCNE1 | |
| SCHEMBL13998623 | 0.85 | GSK3B (0.55) | GSK3BCDK2MAPKAPK2 | |
| SCHEMBL12953634 | 0.84 | GSK3B (0.65) | GSK3BCDK2CCNE1 | |
| SCHEMBL11930864 | 0.84 | GSK3B (0.65) | GSK3BCDK2CCNE1 | |
| SCHEMBL13998536 | 0.84 | GSK3B (0.54) | GSK3BCDK2MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470695-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |
| US-7470695-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |
| EP-1534709-B1 | PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2007044401-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |
| US-7196092-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196092-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |