Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 12/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.33 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1605037 | 1.00 | BRS3 (0.35) | BRS3HPGDPDE3BPDE3AGABBR2 | |
| SCHEMBL1605035 | 1.00 | BRS3 (0.35) | BRS3HPGDPDE3BPDE3AGABBR2 | |
| SCHEMBL13998655 | 1.00 | BRS3 (0.35) | BRS3HPGDPDE3BPDE3AGABBR2 | |
| SCHEMBL13121912 | 1.00 | BRS3 (0.35) | BRS3HPGDPDE3BPDE3AGABBR2 | |
| SCHEMBL1604934 | 1.00 | BRS3 (0.35) | BRS3HPGDPDE3BPDE3AGABBR2 | |
| SCHEMBL1606466 | 1.00 | BRS3 (0.35) | BRS3HPGDPDE3BPDE3AGABBR2 | |
| SCHEMBL1606464 | 1.00 | BRS3 (0.35) | BRS3HPGDPDE3BPDE3AGABBR2 | |
| SCHEMBL14429828 | 1.00 | BRS3 (0.35) | BRS3HPGDPDE3BPDE3AGABBR2 | |
| SCHEMBL1604938 | 1.00 | BRS3 (0.35) | BRS3HPGDPDE3BPDE3AGABBR2 | |
| SCHEMBL1604936 | 1.00 | BRS3 (0.35) | BRS3HPGDPDE3BPDE3AGABBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753736-B1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | AMGEN INC (US) | 2008-12-17 | — | — | EP | disclosed |